@article{21560,
  author = {Beasley R. and Pilcher D. and Finfer Simon and Harrison D. and Rowan K. and Bellomo R. and Young P. and Saxena M. and Myburgh J and Bailey M. and Hyam J. and Menon D.},
  title = {Early temperature and mortality in critically ill patients with acute neurological diseases: trauma and stroke differ from infection},
  abstract = {<p>
BACKGROUND: Fever suppression may be beneficial for patients with traumatic brain injury (TBI) and stroke, but for patients with meningitis or encephalitis [central nervous system (CNS) infection], the febrile response may be advantageous. OBJECTIVE: To evaluate the relationship between peak temperature in the first 24 h of intensive care unit (ICU) admission and all-cause hospital mortality for acute neurological diseases. DESIGN, SETTING AND PARTICIPANTS: Retrospective cohort design from 2005 to 2013, including 934,159 admissions to 148 ICUs in Australia and New Zealand (ANZ) and 908,775 admissions to 236 ICUs in the UK. RESULTS: There were 53,942 (5.8 %) patients in ANZ and 56,696 (6.2 %) patients in the UK with a diagnosis of TBI, stroke or CNS infection. For both the ANZ (P = 0.02) and UK (P &lt; 0.0001) cohorts there was a significant interaction between early peak temperature and CNS infection, indicating that the nature of the relationship between in-hospital mortality and peak temperature differed between TBI/stroke and CNS infection. For patients with CNS infection, elevated peak temperature was not associated with an increased risk of death, relative to the risk at 37-37.4 degrees C (normothermia). For patients with stroke and TBI, peak temperature below 37 degrees C and above 39 degrees C was associated with an increased risk of death, compared to normothermia. CONCLUSIONS: The relationship between peak temperature in the first 24 h after ICU admission and in-hospital mortality differs for TBI/stroke compared to CNS infection. For CNS infection, increased temperature is not associated with increased risk of death.
</p>
},
  year = {2015},
  journal = {Intensive Care Medicine},
  volume = {41},
  edition = {2015/02/04},
  number = {5},
  pages = {823-32},
  month = {-45572182451},
  isbn = {1432-1238 (Electronic)<br/>0342-4642 (Linking)},
  note = {Saxena, Manoj<br/>Young, Paul<br/>Pilcher, David<br/>Bailey, Michael<br/>Harrison, David<br/>Bellomo, Rinaldo<br/>Finfer, Simon<br/>Beasley, Richard<br/>Hyam, Jonathan<br/>Menon, David<br/>Rowan, Kathryn<br/>Myburgh, John<br/>United States<br/>Intensive Care Med. 2015 May;41(5):823-32. doi: 10.1007/s00134-015-3676-6. Epub 2015 Feb 3.},
  language = {eng},
}