@article{21751,
author = {Hu F. and Chasman D. and Ridker P. and Arnett D. and Fornage M. and Wu J. and Psaty B. and Wang L. and Mozaffarian D. and Chu A. and Siscovick D. and Lemaitre R. and King I. and Ma Y. and Djousse L. and Tanaka T. and Smith C. and Follis J. and Nettleton J. and Foy M. and Manichakul A. and Wu H. and Steffen L. and Kabagambe E. and Ferruci L. and Chen Y. and Rich S. and Tang W. and McKnight B. and Tsai M. and Bandinelli S. and Rotter J. and Sun Q. and Lumley T. and Chiuve S. and Ordovas J.},
title = {Dietary fatty acids modulate associations between genetic variants and circulating fatty acids in plasma and erythrocyte membranes: Meta-analysis of nine studies in the CHARGE consortium},
abstract = {
SCOPE: Tissue concentrations of omega-3 fatty acids may reduce cardiovascular disease risk, and genetic variants are associated with circulating fatty acids concentrations. Whether dietary fatty acids interact with genetic variants to modify circulating omega-3 fatty acids is unclear. We evaluated interactions between genetic variants and fatty acid intakes for circulating alpha-linoleic acid, eicosapentaenoic acid, docosahexaenoic acid, and docosapentaenoic acid. METHODS AND RESULTS: We conducted meta-analyses (N = 11 668) evaluating interactions between dietary fatty acids and genetic variants (rs174538 and rs174548 in FADS1 (fatty acid desaturase 1), rs7435 in AGPAT3 (1-acyl-sn-glycerol-3-phosphate), rs4985167 in PDXDC1 (pyridoxal-dependent decarboxylase domain-containing 1), rs780094 in GCKR (glucokinase regulatory protein), and rs3734398 in ELOVL2 (fatty acid elongase 2)). Stratification by measurement compartment (plasma versus erthyrocyte) revealed compartment-specific interactions between FADS1 rs174538 and rs174548 and dietary alpha-linolenic acid and linoleic acid for docosahexaenoic acid and docosapentaenoic acid. CONCLUSION: Our findings reinforce earlier reports that genetically based differences in circulating fatty acids may be partially due to differences in the conversion of fatty acid precursors. Further, fatty acids measurement compartment may modify gene-diet relationships, and considering compartment may improve the detection of gene-fatty acids interactions for circulating fatty acid outcomes.
},
year = {2015},
journal = {Molecular Nutrition and Food Research},
volume = {59},
edition = {2015/01/30},
number = {7},
pages = {1373-83},
isbn = {1613-4133 (Electronic)
1613-4125 (Linking)},
note = {Smith, Caren E
Follis, Jack L
Nettleton, Jennifer A
Foy, Millennia
Wu, Jason H Y
Ma, Yiyi
Tanaka, Toshiko
Manichakul, Ani W
Wu, Hongyu
Chu, Audrey Y
Steffen, Lyn M
Fornage, Myriam
Mozaffarian, Dariush
Kabagambe, Edmond K
Ferruci, Luigi
Chen, Yii-Der Ida
Rich, Stephen S
Djousse, Luc
Ridker, Paul M
Tang, Weihong
McKnight, Barbara
Tsai, Michael Y
Bandinelli, Stefania
Rotter, Jerome I
Hu, Frank B
Chasman, Daniel I
Psaty, Bruce M
Arnett, Donna K
King, Irena B
Sun, Qi
Wang, Lu
Lumley, Thomas
Chiuve, Stephanie E
Siscovick, David S
Ordovas, Jose M
Lemaitre, Rozenn N
AG023629/AG/NIA NIH HHS/United States
CA047988/CA/NCI NIH HHS/United States
CA055075/CA/NCI NIH HHS/United States
DK063491/DK/NIDDK NIH HHS/United States
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R01HL087641/HL/NHLBI NIH HHS/United States
R01HL59367/HL/NHLBI NIH HHS/United States
RR-024156/RR/NCRR NIH HHS/United States
U01-HG-004424/HG/NHGRI NIH HHS/United States
U01-HG-004446/HG/NHGRI NIH HHS/United States
U01-HG-004729/HG/NHGRI NIH HHS/United States
U01HG004402/HG/NHGRI NIH HHS/United States
U01HL072524/HL/NHLBI NIH HHS/United States
UL1 TR000124/TR/NCATS NIH HHS/United States
UL1RR025005/RR/NCRR NIH HHS/United States
UL1TR000124/TR/NCATS NIH HHS/United States
UM1 CA167552/CA/NCI NIH HHS/United States
Intramural NIH HHS/United States
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Germany
Mol Nutr Food Res. 2015 Jul;59(7):1373-83. doi: 10.1002/mnfr.201400734. Epub 2015 Mar 16.},
language = {eng},
}