@article{21794,
  author = {Hawley C. and Pascoe E. and Pedagogos E. and McDonald S. and Zhang L. and Ferrari P. and Johnson D. and Walker R. and Cass A. and Reidlinger D. and Badve S. and Dalziel K. and Clarke P. and Morrish A. and Scaria A. and Vergara L. and Coombes J. and Perkovic Vlado},
  title = {The effect of pentoxifylline on oxidative stress in chronic kidney disease patients with erythropoiesis-stimulating agent hyporesponsiveness: Sub-study of the HERO trial},
  abstract = {<p>
Objective Pentoxifylline has previously been shown to increase haemoglobin levels in patients with chronic kidney disease (CKD) and erythropoietin-stimulating agent (ESA)-hyporesponsive anaemia in the HERO multi-centre double-blind, randomized controlled trial. The present study evaluated the effects of pentoxifylline on oxidative stress in ESA-hyporesponsive CKD patients. Methods This sub-study of the HERO trial compared 15 patients in the pentoxifylline arm (400 mg daily) and 17 in the matched placebo arm on oxidative stress markers: plasma total F2-isoprostanes, protein carbonyls, glutathione peroxidase (GPX), and superoxide dismutase (SOD) activities. Results Pentoxifylline did not significantly alter total F2-isoprostanes (adjusted mean difference (MD) 35.01 pg/ml, P = 0.108), SOD activity (MD 0.82 U/ml, P = 0.073), GPX activity (MD -6.06 U/l, P = 0.085), or protein carbonyls (MD -0.04 nmol/mg, P = 0.523). Replicating results from the main study, pentoxifylline significantly increased haemoglobin concentration compared with controls (MD 7.2 g/l, P = 0.04). Conclusions Pentoxifylline did not alter oxidative stress biomarkers, suggesting that alternative mechanisms may be responsible for the agent's ability to augment haemoglobin levels in CKD patients with ESA-hyporesponsive anaemia.
</p>
},
  year = {2015},
  journal = {Redox Report},
  edition = {2015/06/18},
  isbn = {1743-2928 (Electronic)<br/>1351-0002 (Linking)},
  note = {Zhang, Lei<br/>Coombes, Jeff<br/>Pascoe, Elaine M<br/>Badve, Sunil V<br/>Dalziel, Kim<br/>Cass, Alan<br/>Clarke, Philip<br/>Ferrari, Paolo<br/>McDonald, Stephen P<br/>Morrish, Alicia T<br/>Pedagogos, Eugenie<br/>Perkovic, Vlado<br/>Reidlinger, Donna<br/>Scaria, Anish<br/>Walker, Rowan<br/>Vergara, Liza A<br/>Hawley, Carmel M<br/>Johnson, David W<br/>HERO Study Collaborative Group<br/>Redox Rep. 2015 Jun 17.},
  language = {Eng},
}