@article{22469,
  author = {Kanetsky P. and Dwyer T and Orlow I. and Armstrong B. and Anton-Culver H. and Gruber S. and Gallagher R. and Zanetti R. and Rosso S. and From L. and Busam K. and Cust A. and Begg C. and Berwick M. and Thomas N. and Venn A. and Taylor N. and Nishri D.},
  title = {Nevus count associations with pigmentary phenotype, histopathological melanoma characteristics and survival from melanoma},
  abstract = {<p>
Although nevus count is an established risk factor for melanoma, relationships between nevus number and patient and tumor characteristics have not been well studied and the influence of nevus count on melanoma-specific survival is equivocal. Using data from the Genes, Environment and Melanoma (GEM) study, a large population-based study of primary cutaneous melanoma, we evaluated associations between number of nevi and patient features, including sun-sensitivity summarized in a phenotypic index, and tumor characteristics. We also assessed the association of nevus count with melanoma-specific survival. Higher nevus counts were independently and positively associated with male gender and younger age at diagnosis, and they were inversely associated with lentigo maligna histology. We observed a borderline significant trend of poorer melanoma-specific survival with increasing quartile of nevus count, but little or no association between number of nevi and pigmentary phenotypic characteristics or prognostic tumor features.
</p>
},
  year = {2016},
  journal = {International Journal of Cancer},
  volume = {139},
  edition = {2016/04/23},
  number = {6},
  pages = {1217-22},
  isbn = {1097-0215 (Electronic)<br/>0020-7136 (Linking)},
  note = {Taylor, Nicholas J<br/>Thomas, Nancy E<br/>Anton-Culver, Hoda<br/>Armstrong, Bruce K<br/>Begg, Colin B<br/>Busam, Klaus J<br/>Cust, Anne E<br/>Dwyer, Terence<br/>From, Lynn<br/>Gallagher, Richard P<br/>Gruber, Stephen B<br/>Nishri, Diane E<br/>Orlow, Irene<br/>Rosso, Stefano<br/>Venn, Alison J<br/>Zanetti, Roberto<br/>Berwick, Marianne<br/>Kanetsky, Peter A<br/>GEM Study Group<br/>P30 CA008748/CA/NCI NIH HHS/United States<br/>P30 CA014089/CA/NCI NIH HHS/United States<br/>P30 CA016086/CA/NCI NIH HHS/United States<br/>R01 CA092428/CA/NCI NIH HHS/United States<br/>R01 CA098438/CA/NCI NIH HHS/United States<br/>R01 CA112243/CA/NCI NIH HHS/United States<br/>R01 CA112524/CA/NCI NIH HHS/United States<br/>R25 CA147832/CA/NCI NIH HHS/United States<br/>T32 CA147832/CA/NCI NIH HHS/United States<br/>United States<br/>Int J Cancer. 2016 Sep 15;139(6):1217-22. doi: 10.1002/ijc.30157. Epub 2016 May 30.},
  language = {eng},
}