@article{22919,
  author = {Zheng D and Bei H-Z and You S-J and Zhong C-K and Du H-P and Zhang Y and Lu T-S and Cao L-D and Dong X-F and Cao Y-J and Liu C-F},
  title = {Prognostic role of hypochloremia in acute ischemic stroke patients.},
  abstract = {<p><b>OBJECTIVES: </b>The impact of electrolyte imbalance on clinical outcomes after acute ischemic stroke (AIS) is still not understood. We investigated the association between hypochloremia and hyponatremia upon hospital admission and in-hospital mortality in AIS patients.</p><p><b>MATERIALS AND METHODS: </b>A total of 3314 AIS patients enrolled from December 2013 to May 2014 across 22 hospitals in Suzhou city were included in this study. Hypochloremia was defined as having a serum chloride concentration <98 mmol/L and hyponatremia as having a serum sodium concentration <135 mmol/L. The Cox proportional hazard model was used to examine the effect of hypochloremia and hyponatremia on all-cause in-hospital mortality in AIS patients.</p><p><b>RESULTS: </b>During hospitalization, 118 patients (3.6%) died from all causes. Multivariable model adjusted for age, sex, baseline National Institutes of Health Stroke Scale score, serum sodium, and other potential covariates showed that hypochloremia was associated with a 2.43-fold increase in the risk of in-hospital mortality (hazard ratio [HR] 2.43; 95% confidence interval [CI], 1.41-4.19; P=.001). However, no significant association between hyponatremia (P=.905) and in-hospital mortality was observed. Moreover, the multivariable analysis found that serum chloride (HR=0.92, 95% CI 0.88-0.98; P=.004) but not serum sodium (P=.102) was significantly associated with in-hospital mortality.</p><p><b>CONCLUSIONS: </b>Hypochloremia at admission was independently associated with in-hospital mortality in AIS patients.</p>},
  year = {2017},
  journal = {Acta Neurol Scand},
  volume = {136},
  pages = {672-679},
  issn = {1600-0404},
  doi = {10.1111/ane.12785},
  language = {eng},
}