01653nas a2200157   4500000000100000008004100001100001500042700001400057700001300071245005500084250001500139300001200154490000700166520127600173020004601449       2011                            d1 aHancock M.1 aKamper S.1 aMaher C.00aOptimal designs for prediction studies of whiplash  a2011/10/25  aS268-740 v363 a<p>
STUDY DESIGN: Commentary. OBJECTIVE: To provide guidance for the design and interpretation of predictive studies of whiplash associated disorders (WAD). SUMMARY OF BACKGROUND DATA: Numerous studies have sought to define and explain the clinical course and response to treatment of people with WAD. Design of these studies is often suboptimal, which can lead to biased findings and issues with interpreting the results. METHODS: Literature review and commentary. RESULTS: Predictive studies can be grouped into four broad categories; studies of symptomatic course, studies that aim to identify factors that predict outcome, studies that aim to isolate variables that are causally responsible for outcome, and studies that aim to identify patients who respond best to particular treatments. Although the specific research question will determine the optimal methods, there are a number of generic features that should be incorporated into design of such studies. The aim of these features is to minimize bias, generate adequately precise prognostic estimates, and ensure generalizability of the findings. CONCLUSION: This paper provides a summary of important considerations in the design, conduct, and reporting of prediction studies in the field of whiplash.
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