01706nas a2200265   4500000000100000008004100001100001300042700002200055700001500077700001800092700001800110700001900128700001300147700001400160700001400174700001700188700001500205700001800220245023600238250001500474300001000489490000700499520088800506020004601394       2013                            d1 aLi Qiang1 ade Galan Bastiaan1 aSkulina C.1 aHuxley Rachel1 aWoodward Mark1 aZoungas Sophia1 aBatty G.1 aTaylor B.1 aHarrap S.1 aColagiuri S.1 aNeal Bruce1 aPatel Anushka00aOral disease in relation to future risk of dementia and cognitive decline: Prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial  a2011/10/04  a49-520 v283 a<p>
OBJECTIVE: Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes. METHODS: A total of 11,140 men and women aged 55-88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up. RESULTS: Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95% confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes. CONCLUSIONS: Tooth loss was associated with an increased risk of both dementia and cognitive decline.
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