03113nas a2200421   4500000000100000008004100001653001100042653001100053653000900064653000900073653001600082653002400098653001900122653002400141653003700165653001300202100001900215700001600234700002000250700002100270700002200291700001900313700002800332700001300360700001600373700001800389700002000407700001900427700001800446700001800464700001500482700001300497245016200510300001200672490000700684520198600691022001402677       2016                            d10aFemale10aHumans10aAged10aMale10aMiddle Aged10aSingle-Blind Method10aBlood Pressure10aCerebral Hemorrhage10aOutcome Assessment (Health Care)10aHematoma1 aAnderson Craig1 aHeeley Emma1 aStapf Christian1 aDelcourt Candice1 aRobinson Thompson1 aArima Hisatomi1 aINTERACT2 Investigators1 aWang Xia1 aChalmers J.1 aLavados Pablo1 aLindley Richard1 aSato Shoichiro1 aZhang Shihong1 aSalman Rustam1 aDavies Leo1 aLiu Ming00aSignificance of Hematoma Shape and Density in Intracerebral Hemorrhage: The Intensive Blood Pressure Reduction in Acute Intracerebral Hemorrhage Trial Study.  a1227-320 v473 a<p>
<b>BACKGROUND AND PURPOSE: </b>In patients with acute intracerebral hemorrhage (ICH), the shape and density of the hematoma are associated with its subsequent growth, but the impact of these parameters on clinical outcome is uncertain.
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<b>METHODS: </b>Baseline computed tomographic scans and clinical data were obtained in the Intensive Blood Pressure Reduction in Acute Intracerebral Hemorrhage Trial (INTERACT2). Three independent neurologists blind to clinical data assessed ICH for shape and density using a previously described scale. Shape was defined as irregular when the ICH had ≥2 extra lesions added to the ellipsoid-shaped ICH. Density was heterogeneous when there were ≥3 low-density lesions within the ICH. Outcome measures were death and major disability (modified Rankin scale score of 3-5), combined and separate at 90-day postrandomization. Multivariable logistic regression models were used to determine the significance of hematoma characteristics on outcome.
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<b>RESULTS: </b>There were 2066 patient computed tomographic scans included in the analysis, with 46% and 38% having irregular and heterogeneous ICH, respectively. Irregular shape was independently associated with death/major disability (adjusted odds ratio, 1.60; 95% confidence interval [CI], 1.29-1.98) and major disability alone (adjusted odds ratio, 1.60; 95% CI, 1.31-1.95), but not with death alone (adjusted odds ratio, 0.97; 95% CI, 0.68-1.39). Heterogeneous density was not associated with clinical outcomes (adjusted odds ratio, 1.06; 95% CI, 0.85-1.33), 1.04 (95% CI, 0.73-1.48), and 1.14 (95% CI, 0.93-1.39), respectively, for death/major disability, death alone, and disability alone).
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<b>CONCLUSIONS: </b>Irregular shape, but not heterogeneous density, is independently associated with poor outcome after ICH.
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<b>CLINICAL TRIAL REGISTRATION: </b>URL: http://www.clinicaltrials.gov. Unique identifier: NCT00716079.
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