02277nas a2200349   4500000000100000008004100001260001700042100001700059700001100076700002300087700001700110700001600127700002200143700001500165700001600180700001600196700001900212700002100231700001400252700002000266700001500286700001400301700002100315700001800336700001600354700005700370245012500427300001200552490000700564520134200571022001401913       2018                            d  c-242712097221 aGallagher M.1 aDu Bin1 aVincent Jean-Louis1 aPeng Zhiyong1 aYu Kaijiang1 aOstermann Marlies1 aXi XiuMing1 aHsu Raymond1 aProwle John1 aWang Changsong1 aMurugan Raghavan1 aQiu Haibo1 aRimmelé Thomas1 aLi Jianguo1 aForni Lui1 aKashani Kianoush1 aRonco Claudio1 aKellum John1 aAcute Disease Quality Initiative (ADQI) Workgroup 1900aPragmatic studies for acute kidney injury: Consensus report of the Acute Disease Quality Initiative (ADQI) 19 Workgroup.  a337-3440 v443 a<p><b>PURPOSE: </b>Acute kidney injury (AKI) has become a major medical and financial burden in China along with the rest of the world. There have been considerable advances in the understanding of the epidemiology and pathogenesis of AKI. However, there is no consensus regarding the optimal care for patients. The Acute Disease Quality Initiative (ADQI) 19 meeting focused on identifying and designing relevant and achievable AKI-related studies in China.</p><p><b>MATERIALS & METHODS: </b>The working group developed a list of preliminary questions and objectives and performed analysis of the existing literature. Relevant studies were identified through a literature search using the MEDLINE database and bibliographies of relevant research and review articles. We then used a two-step Delphi process to prioritize a research agenda and proposed specific study designs to address unmet needs.</p><p><b>RESULTS: </b>Important gaps in existing knowledge were identified and pragmatic studies were proposed in three distinct areas: care bundles for AKI prevention, renal replacement therapy (RRT) for AKI, and fluid management. In addition, the use of biomarkers to guide clinical trials was discussed.</p><p><b>CONCLUSIONS: </b>Consensus was reached on a research agenda for AKI with a specific focus on pragmatic trials in China.</p>  a1557-8615