BACKGROUND: =0.24) or on total mortality (RR=0.95; 95% CI, 0.86-1.04; P=0.28). omega-3 FA did protect against vascular death (RR=0.86; 95% CI, 0.75-0.99; P=0.03) but not coronary events (RR=0.86; 95% CI, 0.67-1.11; P=0.24). There was no effect on arrhythmia (RR=0.99; 95% CI, 0.85-1.16; P=0.92) or cerebrovascular events (RR=1.03; 95% CI, 0.92-1.16; P=0.59). Adverse events were more common in the treatment group than the placebo group (RR=1.18, 95% CI, 1.02-1.37; P=0.03), predominantly because of an excess of gastrointestinal side effects.Conclusions-omega-3 FA may protect against vascular disease, but the evidence is not clear-cut, and any benefits are almost certainly not as great as previously believed.
AD - George Institute for Global Health, University of Sydney, Sydney, Australia. AN - 23110790 BT - Circulation: Cardiovascular Quality and Outcomes DP - NLM ET - 2012/11/01 LA - Eng N1 - Kotwal, SradhaJun, MinSullivan, DavidPerkovic, VladoNeal, BruceCirc Cardiovasc Qual Outcomes. 2012 Oct 30. N2 -BACKGROUND: =0.24) or on total mortality (RR=0.95; 95% CI, 0.86-1.04; P=0.28). omega-3 FA did protect against vascular death (RR=0.86; 95% CI, 0.75-0.99; P=0.03) but not coronary events (RR=0.86; 95% CI, 0.67-1.11; P=0.24). There was no effect on arrhythmia (RR=0.99; 95% CI, 0.85-1.16; P=0.92) or cerebrovascular events (RR=1.03; 95% CI, 0.92-1.16; P=0.59). Adverse events were more common in the treatment group than the placebo group (RR=1.18, 95% CI, 1.02-1.37; P=0.03), predominantly because of an excess of gastrointestinal side effects.Conclusions-omega-3 FA may protect against vascular disease, but the evidence is not clear-cut, and any benefits are almost certainly not as great as previously believed.
PY - 2012 SN - 1941-7705 (Electronic)1941-7713 (Linking) T2 - Circulation: Cardiovascular Quality and Outcomes TI - Omega 3 Fatty Acids and Cardiovascular Outcomes: Systematic Review and Meta-Analysis ER -