The primary aim was to determine whether the presence of metabolic syndrome (MetS) limits aerobic fitness in patients with schizophrenia. A secondary aim was to investigate the associations between aerobic fitness and MetS parameters. Aerobic fitness (expressed as predicted maximal oxygen uptake) was assessed using the Astrand-Rhyming test. Those with MetS (n = 19) were similar in age, sex, antipsychotic medication use, symptoms, and smoking behavior than those without (n = 31). Estimated maximal oxygen uptake was 21.4% lower (p = 0.001) in patients with MetS than in patients without MetS (29.5 +/- 7.4 ml of O2/min/kg vs. 37.5 +/- 8.2 ml of O2/min/kg, respectively). The estimated maximal oxygen uptake of the entire sample was correlated with waist circumference, the level of high-density lipoproteins, and fasting glucose. The current study demonstrates that the additive burden of MetS might place people with schizophrenia at increased risk for functional limitations in daily life activities.
AD - *Department of Rehabilitation Sciences, KU Leuven, Belgium; daggerKU Leuven Department of Neurosciences, UPC KU Leuven (Campus Kortenberg), Belgium; double daggerSchool of Health and Social Care, University of Greenwich, London, UK; section signSchool of Psychiatry, University of New South Wales, Sydney, Australia; parallelSchizophrenia Research Unit, South Western Sydney Local Health District, Liverpool, Australia; paragraph signMusculoskeletal Division, The George Institute for Global Health, Sydney, Australia; and **School of Public Health, University of Sydney, Australia. AN - 25494336 BT - Journal of Nervous and Mental Disease DP - NLM ET - 2014/12/11 IS - 1 LA - Eng LB - MSK N1 - Vancampfort, DavyThe primary aim was to determine whether the presence of metabolic syndrome (MetS) limits aerobic fitness in patients with schizophrenia. A secondary aim was to investigate the associations between aerobic fitness and MetS parameters. Aerobic fitness (expressed as predicted maximal oxygen uptake) was assessed using the Astrand-Rhyming test. Those with MetS (n = 19) were similar in age, sex, antipsychotic medication use, symptoms, and smoking behavior than those without (n = 31). Estimated maximal oxygen uptake was 21.4% lower (p = 0.001) in patients with MetS than in patients without MetS (29.5 +/- 7.4 ml of O2/min/kg vs. 37.5 +/- 8.2 ml of O2/min/kg, respectively). The estimated maximal oxygen uptake of the entire sample was correlated with waist circumference, the level of high-density lipoproteins, and fasting glucose. The current study demonstrates that the additive burden of MetS might place people with schizophrenia at increased risk for functional limitations in daily life activities.
PY - 2015 SN - 1539-736X (Electronic)