TY - JOUR
AU - Wu J.
AU - Song X.
AU - Yang J.
AU - Mozaffarian D.
AU - Akintoye E.
AU - Hou T.
AU - Hammock B.
AB - <p>
Objective Our objective was to assess the dynamics of monoepoxides derived from polyunsaturated fatty acids (MEFAs), and their response to n-3 PUFA supplementation, in the setting of acute tissue injury and inflammation (cardiac surgery) in humans. Methods and Results 479 patients undergoing cardiac surgery in three countries were randomized to peri-operative fish oil (EPA+DHA; 8-10g over 2-5 days pre-operatively then 2 g/d post-operatively) or placebo (olive oil). Plasma MEFAs derived from n-3 and n-6 PUFA were measured 2 days post-operatively. Based on serial measures in a subset of the placebo group, levels of all MEFAs declined from enrollment to post-op day 2, with declines ranging from 37 to 63% (P&lt;0.05 each). Compared to placebo at post-op day 2, levels of EPA- and DHA-derived MEFAs were 40% and 18% higher, respectively (P<!--=0.004). n-3 PUFA supplementation did not significantly alter n-6 PUFA-derived MEFAs. Both enrollment level and changes in plasma phospholipid EPA and DHA were associated with their respective MEFAs at post-op day-2 (p<0.001). Conclusions Under the acute stress of cardiac surgery, n-3 PUFA supplementation significantly ameliorated the reduction in post-operative n-3 MEFAs, but not n-6 MEFAs; and levels of increase related to circulating n-3 PUFA precursors.-->
</p>

AD - Wayne State University School of Medicine, United States;<br/>The George Institute for Global Health, Australia;<br/>Harvard Universtiy School of Public Health, United States;<br/>Fred Hutchinson Cancer Research Center, United States;<br/>UC Davis Comprehensive Cancer Center, University of California Davis, United States;<br/>UC Davis, United States;<br/>Friedman School of Nutrition Science & Policy, Tufts University dariush.mozaffarian@tufts.edu.
AN - 26749073
BT - Journal of Lipid Research
DA - 93562401117
DP - NLM
ET - 2016/01/11
LA - Eng
LB - FY16<br/>AUS<br/>FP
M1 - 3
N1 - Akintoye, Emmanuel<br/>Wu, Jason H Y<br/>Hou, Tao<br/>Song, Xiaoling<br/>Yang, Jun<br/>Hammock, Bruce<br/>Mozaffarian, Dariush<br/>J Lipid Res. 2016 Jan 9. pii: jlr.P062398.
N2 - <p>
Objective Our objective was to assess the dynamics of monoepoxides derived from polyunsaturated fatty acids (MEFAs), and their response to n-3 PUFA supplementation, in the setting of acute tissue injury and inflammation (cardiac surgery) in humans. Methods and Results 479 patients undergoing cardiac surgery in three countries were randomized to peri-operative fish oil (EPA+DHA; 8-10g over 2-5 days pre-operatively then 2 g/d post-operatively) or placebo (olive oil). Plasma MEFAs derived from n-3 and n-6 PUFA were measured 2 days post-operatively. Based on serial measures in a subset of the placebo group, levels of all MEFAs declined from enrollment to post-op day 2, with declines ranging from 37 to 63% (P&lt;0.05 each). Compared to placebo at post-op day 2, levels of EPA- and DHA-derived MEFAs were 40% and 18% higher, respectively (P<!--=0.004). n-3 PUFA supplementation did not significantly alter n-6 PUFA-derived MEFAs. Both enrollment level and changes in plasma phospholipid EPA and DHA were associated with their respective MEFAs at post-op day-2 (p<0.001). Conclusions Under the acute stress of cardiac surgery, n-3 PUFA supplementation significantly ameliorated the reduction in post-operative n-3 MEFAs, but not n-6 MEFAs; and levels of increase related to circulating n-3 PUFA precursors.-->
</p>

PY - 2016
SN - 0022-2275 (Electronic)<br/>0022-2275 (Linking)
SP - 492
EP - 8
T2 - Journal of Lipid Research
TI - Effect of Fish Oil on Monoepoxides Derived from Fatty Acids during Cardiac Surgery
VL - 57
Y2 - FY16
ER -