STUDY DESIGN: Systematic review OBJECTIVE.: To investigate whether MRI findings change over a relatively short period of time (< 1 year) in people with LBP or sciatica. We also investigated whether there was an association between any change in MRI findings and change in clinical outcomes. SUMMARY OF BACKGROUND DATA: MRI offers the potential to identify possible pathoanatomic sources of low back pain (LBP) and/or sciatica; however, the clinical importance of MRI findings remains unclear. Little is known about whether lumbar MRI findings change over the short term and if so whether these changes are associated with changes in clinical outcomes. METHODS: Medline, Embase and CINAHL databases were searched. Included were cohort studies that performed repeat MRI scans within 12 months in patients with LBP and/or sciatica. Data on study characteristics and change in MRI findings were extracted from included studies. Any data describing associations between change in MRI findings and change in clinical outcomes were also extracted. RESULTS: A total of 12 studies met the inclusion criteria and were included in the review. Pooling was not possible due to heterogeneity of studies and findings. Seven studies reported on changes in disc herniation and reported 15% - 93% of herniations reduced or disappeared in size. Two studies reported on changes in nerve root compression and reported 17% - 91% reduced or disappeared. Only one study reported on the association between change in MRI findings and change in clinical outcomes within 1 year, and found no association. CONCLUSIONS: This review found moderate evidence that the natural course of herniations and nerve root compression is favourable over a 1-year period in people with sciatica or LBP. There is a lack of evidence on whether other MRI findings change, and if changes in MRI findings are associated with changes in clinical outcomes. LEVEL OF EVIDENCE: 1.
AD - *Faculty of Medicine and Health Sciences, Macquarie University, Australia daggerFaculty of Medicine and Health Sciences, Macquarie University, Australia double daggerThe George Institute for Global Health, Australia section signFaculty of Medicine and Health Sciences, Macquarie University, Australia. AN - 27428391 BT - Spine CN - [IF]: 2.297 DP - NLM ET - 2016/07/19 LA - Eng LB - AUSSTUDY DESIGN: Systematic review OBJECTIVE.: To investigate whether MRI findings change over a relatively short period of time (< 1 year) in people with LBP or sciatica. We also investigated whether there was an association between any change in MRI findings and change in clinical outcomes. SUMMARY OF BACKGROUND DATA: MRI offers the potential to identify possible pathoanatomic sources of low back pain (LBP) and/or sciatica; however, the clinical importance of MRI findings remains unclear. Little is known about whether lumbar MRI findings change over the short term and if so whether these changes are associated with changes in clinical outcomes. METHODS: Medline, Embase and CINAHL databases were searched. Included were cohort studies that performed repeat MRI scans within 12 months in patients with LBP and/or sciatica. Data on study characteristics and change in MRI findings were extracted from included studies. Any data describing associations between change in MRI findings and change in clinical outcomes were also extracted. RESULTS: A total of 12 studies met the inclusion criteria and were included in the review. Pooling was not possible due to heterogeneity of studies and findings. Seven studies reported on changes in disc herniation and reported 15% - 93% of herniations reduced or disappeared in size. Two studies reported on changes in nerve root compression and reported 17% - 91% reduced or disappeared. Only one study reported on the association between change in MRI findings and change in clinical outcomes within 1 year, and found no association. CONCLUSIONS: This review found moderate evidence that the natural course of herniations and nerve root compression is favourable over a 1-year period in people with sciatica or LBP. There is a lack of evidence on whether other MRI findings change, and if changes in MRI findings are associated with changes in clinical outcomes. LEVEL OF EVIDENCE: 1.
PY - 2016 SN - 1528-1159 (Electronic)