TY - JOUR
AU - Kanetsky P.
AU - Dwyer T
AU - Orlow I.
AU - Armstrong B.
AU - Anton-Culver H.
AU - Gruber S.
AU - Gallagher R.
AU - Zanetti R.
AU - Rosso S.
AU - From L.
AU - Busam K.
AU - Cust A.
AU - Begg C.
AU - Berwick M.
AU - Thomas N.
AU - Venn A.
AU - Taylor N.
AU - Nishri D.
AB - <p>
Although nevus count is an established risk factor for melanoma, relationships between nevus number and patient and tumor characteristics have not been well studied and the influence of nevus count on melanoma-specific survival is equivocal. Using data from the Genes, Environment and Melanoma (GEM) study, a large population-based study of primary cutaneous melanoma, we evaluated associations between number of nevi and patient features, including sun-sensitivity summarized in a phenotypic index, and tumor characteristics. We also assessed the association of nevus count with melanoma-specific survival. Higher nevus counts were independently and positively associated with male gender and younger age at diagnosis, and they were inversely associated with lentigo maligna histology. We observed a borderline significant trend of poorer melanoma-specific survival with increasing quartile of nevus count, but little or no association between number of nevi and pigmentary phenotypic characteristics or prognostic tumor features.
</p>

AD - Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.<br/>Department of Dermatology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC.<br/>Department of Epidemiology, University of California, Irvine, CA.<br/>School of Public Health, University of Sydney, Sydney, NSW, Australia.<br/>Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.<br/>Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.<br/>George Institute for Global Health Research, University of Oxford, Oxford, United Kingdom.<br/>Women's College Hospital, Toronto, ON, Canada.<br/>British Columbia Cancer Research Centre, Vancouver, BC, Canada.<br/>Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA.<br/>Cancercare Ontario, Toronto, ON, Canada.<br/>Piedmont Tumor Registry, Turin, Italy.<br/>Menzies Centre for Population Health, University of Tasmania, Hobart, Tasmania, Australia.<br/>Departments of Internal Medicine and Dermatology, University of New Mexico, Albuquerque, NM.
AN - 27101944
BT - International Journal of Cancer
C2 - PMC4939099
C6 - Nihms781470
CN - [if]: 5.085
DP - NLM
ET - 2016/04/23
LA - eng
LB - UK<br/>FY17
M1 - 6
N1 - Taylor, Nicholas J<br/>Thomas, Nancy E<br/>Anton-Culver, Hoda<br/>Armstrong, Bruce K<br/>Begg, Colin B<br/>Busam, Klaus J<br/>Cust, Anne E<br/>Dwyer, Terence<br/>From, Lynn<br/>Gallagher, Richard P<br/>Gruber, Stephen B<br/>Nishri, Diane E<br/>Orlow, Irene<br/>Rosso, Stefano<br/>Venn, Alison J<br/>Zanetti, Roberto<br/>Berwick, Marianne<br/>Kanetsky, Peter A<br/>GEM Study Group<br/>P30 CA008748/CA/NCI NIH HHS/United States<br/>P30 CA014089/CA/NCI NIH HHS/United States<br/>P30 CA016086/CA/NCI NIH HHS/United States<br/>R01 CA092428/CA/NCI NIH HHS/United States<br/>R01 CA098438/CA/NCI NIH HHS/United States<br/>R01 CA112243/CA/NCI NIH HHS/United States<br/>R01 CA112524/CA/NCI NIH HHS/United States<br/>R25 CA147832/CA/NCI NIH HHS/United States<br/>T32 CA147832/CA/NCI NIH HHS/United States<br/>United States<br/>Int J Cancer. 2016 Sep 15;139(6):1217-22. doi: 10.1002/ijc.30157. Epub 2016 May 30.
N2 - <p>
Although nevus count is an established risk factor for melanoma, relationships between nevus number and patient and tumor characteristics have not been well studied and the influence of nevus count on melanoma-specific survival is equivocal. Using data from the Genes, Environment and Melanoma (GEM) study, a large population-based study of primary cutaneous melanoma, we evaluated associations between number of nevi and patient features, including sun-sensitivity summarized in a phenotypic index, and tumor characteristics. We also assessed the association of nevus count with melanoma-specific survival. Higher nevus counts were independently and positively associated with male gender and younger age at diagnosis, and they were inversely associated with lentigo maligna histology. We observed a borderline significant trend of poorer melanoma-specific survival with increasing quartile of nevus count, but little or no association between number of nevi and pigmentary phenotypic characteristics or prognostic tumor features.
</p>

PY - 2016
SN - 1097-0215 (Electronic)<br/>0020-7136 (Linking)
SP - 1217
EP - 22
T2 - International Journal of Cancer
TI - Nevus count associations with pigmentary phenotype, histopathological melanoma characteristics and survival from melanoma
VL - 139
Y2 - FY17
ER -