TY - JOUR
KW - Female
KW - Humans
KW - Aged
KW - Male
KW - Middle Aged
KW - Risk Factors
KW - Blood Pressure
KW - Cerebral Hemorrhage
KW - Cold Temperature
AU - Anderson Craig
AU - Heeley Emma
AU - Huang Yining
AU - Wang Jiguang
AU - Stapf Christian
AU - Delcourt Candice
AU - Robinson Thompson
AU - Lavados Pablo
AU - Arima Hisatomi
AU - INTERACT2 Investigators
AU - Chalmers J.
AU - Lo Serigne
AU - Sato Shoichiro
AU - Zheng Danni
AU - Gasparrini Antonio
AB - <p>
<b>BACKGROUND: </b>Rates of acute intracerebral hemorrhage (ICH) increase in winter months but the magnitude of risk is unknown. We aimed to quantify the association of ambient temperature with the risk of ICH in the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT2) participants on an hourly timescale.
</p>

<p>
<b>METHODS: </b>INTERACT2 was an international, open, blinded endpoint, randomized controlled trial of patients with spontaneous ICH (&lt;6h of onset) and elevated systolic blood pressure (SBP, 150-220 mmHg) assigned to intensive (target SBP &lt;140 mmHg) or guideline-recommended (SBP &lt;180 mmHg) BP treatment. We linked individual level hourly temperature to baseline data of 1997 participants, and performed case-crossover analyses using a distributed lag non-linear model with 24h lag period to assess the association of ambient temperature and risk of ICH. Results were presented as overall cumulative odds ratios (ORs) and 95% CI.
</p>

<p>
<b>RESULTS: </b>Low ambient temperature (≤10°C) was associated with increased risks of ICH: overall cumulative OR was 1.37 (0.99-1.91) for 10°C, 1.92 (1.31-2.81) for 0°C, 3.13 (1.89-5.19) for -10°C, and 5.76 (2.30-14.42) for -20°C, as compared with a reference temperature of 20°C.There was no clear relation of low temperature beyond three hours after exposure. Results were consistent in sensitivity analyses.
</p>

<p>
<b>CONCLUSIONS: </b>Exposure to low ambient temperature within several hours increases the risk of ICH.
</p>

<p>
<b>TRIAL REGISTRATION: </b>ClinicalTrials.gov NCT00716079.
</p>

BT - PLoS One
DO - 10.1371/journal.pone.0149040
IS - 2
J2 - PLoS ONE
LA - eng
N2 - <p>
<b>BACKGROUND: </b>Rates of acute intracerebral hemorrhage (ICH) increase in winter months but the magnitude of risk is unknown. We aimed to quantify the association of ambient temperature with the risk of ICH in the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT2) participants on an hourly timescale.
</p>

<p>
<b>METHODS: </b>INTERACT2 was an international, open, blinded endpoint, randomized controlled trial of patients with spontaneous ICH (&lt;6h of onset) and elevated systolic blood pressure (SBP, 150-220 mmHg) assigned to intensive (target SBP &lt;140 mmHg) or guideline-recommended (SBP &lt;180 mmHg) BP treatment. We linked individual level hourly temperature to baseline data of 1997 participants, and performed case-crossover analyses using a distributed lag non-linear model with 24h lag period to assess the association of ambient temperature and risk of ICH. Results were presented as overall cumulative odds ratios (ORs) and 95% CI.
</p>

<p>
<b>RESULTS: </b>Low ambient temperature (≤10°C) was associated with increased risks of ICH: overall cumulative OR was 1.37 (0.99-1.91) for 10°C, 1.92 (1.31-2.81) for 0°C, 3.13 (1.89-5.19) for -10°C, and 5.76 (2.30-14.42) for -20°C, as compared with a reference temperature of 20°C.There was no clear relation of low temperature beyond three hours after exposure. Results were consistent in sensitivity analyses.
</p>

<p>
<b>CONCLUSIONS: </b>Exposure to low ambient temperature within several hours increases the risk of ICH.
</p>

<p>
<b>TRIAL REGISTRATION: </b>ClinicalTrials.gov NCT00716079.
</p>

PY - 2016
EP - e0149040
T2 - PLoS One
TI - Low Ambient Temperature and Intracerebral Hemorrhage: The INTERACT2 Study.
VL - 11
SN - 1932-6203
ER -