%0 Journal Article %K Humans %K Randomised Controlled Trials %K Treatment Outcome %K Apache %K Placebos %K Questionnaires %K Research Design %K United States Food and Drug Administration %K United States %K Protein C %K Therapeutic use %K Clinical Trials %K Multicenter Studies as Topic %K Recombinant Proteins %K Anti-Infective Agents %K Septic Shock %K Drug Industry %K Ethics %B Intensive Care Medicine %D 2008 %G eng %M 18839141 %P 1935-47 %T Design, conduct, analysis and reporting of a multi-national placebo-controlled trial of activated protein C for persistent septic shock %V 34 %2 2995439 %7 2008/10/08 %8 128306597146 %@ 0342-4642 (Print)0342-4642 (Linking) %! Intensive Care Med.Intensive Care Med.