Innovative clinical trials

Researchers at The George Institute for Global Health, UK, led by Executive Director Professor Otavio Berwanger, are spearheading a programme of work to transform that way we deliver large-scale clinical trials.

This programme is borne out of a recognition of the limitations of the ‘traditional’ clinical trial model – and the health gains (social, environmental and economic) – to be had in investigating pragmatic, innovative and efficient approaches.

Event

One too Many? The link between alcohol and cancer

New Zealanders support alcohol control

Join C3 Collaborating for Health and The George Institute this London Global Cancer Week (11-17 November 2023) as we explore how best to reduce alcohol consumption and raise awareness in the global fight against cancer.

  • Time: 16th November 2023
  • Date: 08:30-10:00 GMT/ 09:30-11:00 CET/14:00-15:30 IST/19:30-21:00 AEST
  • Format: Online

REGISTER HERE

Cancer has become the second leading cause of death globally. Cancer impacts on national economies through increased out-of-pocket health expenditure, labour, and productivity losses, which often drives families caring for cancer patients into poverty. London Global Cancer Week (LGCW) brings together researchers, policy makers, health professionals and other key stakeholders from across the world to create a 360° picture of the impact of the rising global prevalence of cancer, and the challenges the cancer pandemic poses to realising Universal health coverage.

Even small amounts of alcohol can increase your risk of cancer, so the more you can cut down the more you can reduce the risk. In this session, experts from different sectors will discuss how alcohol contributes to cancer risk and how we can best address alcohol consumption and raise awareness of its health risks by sharing evidence-based approaches for reducing alcohol consumption in societies where ‘drinking’ is a socio-cultural norm. During the Q&A, audience members will have the opportunity to provide new insights and opportunities for change.

Agenda (times are displayed in GMT)

  • 08:30-08:50 - Opening remarks and introductions from speakers (Christine Hancock, Founder & Director, C3 Collaborating for Health)
  • 08:50-09:00 - Proven policy solutions to raise awareness and prevent cancer cases and deaths due to alcohol across the globe (Maik Dünnbier, Director of Advocacy and Strategy, Movendi International)
  • 09:00-09:30 - Panel discussion: regional exchange on progress and priorities
    • Dr Carina Ferreira-Borges, Regional Advisor Alcohol, illicit drugs, prison health, WHO Regional Office for Europe
    • Liz Arnanz, Policy and Advocacy Manager, NCD Alliance
    • Professor Simone Pettigrew, Director of Health Promotion and Behaviour Change, The George Institute for Global Health
  • 09:30-09:55 – Q & A
  • 09:55-10:00 - Closing remarks (Christine Hancock, Founder & Director, C3 Collaborating for Health)

Speakers

  • Dr Carina Ferreira-Borges

    Dr Carina Ferreira-Borges is a public health specialist with an interest in non-communicable diseases and holds a PhD in International Health. She joined WHO in 2006 dedicating her work to strengthening WHO normative and technical support to countries namely the development of comprehensive national policies aimed at reducing alcohol consumption and the improvement of prison health systems. In addition, Carina was Head of the WHO Office for Prevention and Control of NCDs and NCD Director providing strategic and technical support to 53 Member States of the Region in scaling up their efforts to better prevent and control noncommunicable diseases.

     

    Dr Carina Ferreira-Borges
  • Christine Hancock

    Christine Hancock is the founder and director of C3 Collaborating for Health, a UK-based NGO aimed at preventing NCDs. She is a graduate of the London School of Economics and an experienced nurse and health service manager.

    Christine Hancock
  • Liz Arnanz

    Liz Arnanz is responsible for NCD Alliance’s policy and advocacy work on noncommunicable disease (NCD) prevention and health promotion, by advocating and supporting the implementation of regulations and policies that reduce exposure to the main NCD risk factors and address the social and commercial determinants of health. Prior to this, she worked at FDI World Dental Federation, advocating for the integration of oral health promotion and care within health systems and public health policy, and for the partnerships and membership team of the NCD Alliance. She also has experience in the field of humanitarian aid and protection and has been a consultant with the UN Population Fund (UNFPA). She holds a Master’s degree in European Interdisciplinary Studies from the College of Europe, and is fluent in English, French and Spanish.

    Liz Arnanz
  • Maik Dünnbier

    Maik Dünnbier from Cottbus, Germany, is the first ever Director of Strategy and Advocacy in the 170-year long history of Movendi International. He works closely together with the Executive Director and advises the President and International Board on strategic questions and advocacy issues. Maik is a political scientist, advocacy specialist, civil society activist, communication expert, fearless thinker and innovator, a Human Rights defender and humanist. Maik leads Movendi International with creativity, heart-driven passion, and critical thinking. Maik’s work is guided and inspired by their vision for a world where free and healthy citizens actively contribute to all levels of society.

    Maik Dünnbier
  • Professor Simone Pettigrew

    Professor Simone Pettigrew is Director of Health Promotion and Behaviour Change. She has qualifications in Economics, Marketing, and Consumer Psychology. Her broad areas of expertise include behavioural psychology, health promotion, health policy, communications, social marketing, and intervention research. Her substantive areas of research include alcohol consumption, smoking, vaping, nutrition, obesity, physical activity, active transport, and healthy ageing. Simone sits on numerous advisory committees and regularly performs research consultancies for NGO and government entities. To date, she has published more than 400 peer-reviewed papers and produced more than 160 technical reports for NGOs and government departments.

    Professor Simone Pettigrew
Brain drain in Southern Africa

Brain drain in Southern Africa: funded healthcare training programs aren’t keeping workers where they are needed

Researchers find ‘return-of-service’ agreements are not effective in retaining skilled healthcare workers in four Southern African countries, but identify factors for better outcomes.

Millions of people around the world are struggling to access healthcare, and it’s predicted to get worse. Global shortages of doctors, nurses and midwives is expected to reach 10 million by 2030. For resource-limited nations, who must compete with high-income countries to train and retain skilled health professionals, this is a significant challenge to public health.

To keep skilled workers in country, policymakers in Africa and elsewhere have invested heavily in ‘return-of-service’ agreements. Individuals receive government funded health worker training, in exchange for a commitment to serve in an underserved community for a specified period of time.

For the first time, a UNSW-led retrospective cohort study has evaluated the effectiveness of return-of-service agreements in South Africa, Botswana, Eswatini and Lesotho.

Despite being used extensively, the effectiveness (where effectiveness relates to the retention of health workers) of these costly schemes in low- and middle-income countries has been until now unknown. It's vital that these schemes are successful in resource-limited nations.

Interviews we’ve led with key policymakers running these schemes in South Africa, Botswana, Eswatini and Lesotho, suggested that the agreements have been hampered by poor planning and information systems, high defaulter rates, and a lack of reviews to understand the impact of these policies on society’s health and wellbeing,” says Dr Sikhumbuzo A. Mabunda, a researcher at the UNSW School of Population Health and The George Institute for Global Health, which is affiliated with UNSW.

The research team assessed the percentage of beneficiaries (individuals who received government-funded training) who fulfilled their contractual obligations, and those who remained in service beyond their contractual agreements.

The findings were published in BMJ Global Health Journal this week.

They reviewed data from the national governments of Eswatini, Lesotho and Botswana and South African state governments. They looked at a range of beneficiaries (doctors, pharmacists, dentists, physiotherapists, audiologists, speech therapists, occupational therapists and specialist doctors) supported between the years 2000 and 2010. They also requested information on beneficiaries’ work records up to March 2023.

The research was funded by UNSW, the National Heart Foundation and the National Health and Medical Research Council.

Defaulting on contracts is common

Despite the challenges of modest data systems, the research team were able to obtain data for 5,616 of an expected 14,000 beneficiaries. The high proportion of missing data could suggest that many beneficiaries are not being tracked.

The results did not find that return-of-service agreement schemes are effective in retaining healthcare professionals.

“Of the individuals with data available, only 19% had full information on their work history. Of those with full information, 67% defaulted their contracts and only 22% served their contracts,” says lead author Dr Mabunda.

Local internships have best outcomes

However, the research team identified a few factors associated with better outcomes.

“Beneficiaries who undertook their practical internship within the funding province were far more likely to be retained in service. We found that governments needed to fund six beneficiaries to have one beneficiary fulfilling their contractual agreements if they undertook internship outside their province,” says senior author of the study Associate Professor Rohina Joshi, a researcher at the School of Population Health and an affiliate of The George Institute for Global Health India.

“Unfortunately, only 32% of the 861 individuals who were supposed to do such an internship, undertook it within their province,” adds study co-author and researcher at The George Institute for Global Health in Sydney, Dr Blake Angell.

Current policy allows beneficiaries to undertake internship training outside their funding province. This study is the first to find that this practice is associated with higher defaulter rates.

Implications for policy makers

Dr Mabunda notes that the schemes have seen sustained investment over many decades and seemingly enjoy good political support, and that it is important to make the most of that goodwill. In the short term, Dr Mabunda believes that the governments should look to strengthen their technical capacities for managing these schemes, and strengthen information systems to capture the beneficiary life cycle. The schemes can be made more resilient through linking to research and evidence, implementing regular reviews, assessing impacts and retaining data.

Importantly, the study authors recommend that long term, internships should be undertaken within the funding jurisdiction, and governments must build internal capacity for training graduates they need within their own jurisdictions.

Variants of these schemes have been used in countries of all income levels with limited evidence that they are an effective mechanism to build a high-quality health workforce.

“Insights into their operation such as those we have generated through this study offer governments the chance to reflect on these programs and consider ways to improve their success in building an effective health workforce,” Dr Angell adds.

“Countries like Australia, who implement similar agreements, have a lot to learn from the experiences of these four countries to help improve the availability of health workers in regional areas.”

Meet Laure Philip, Development Manager, Major Gifts, The George Institute

In search of a career with an immediate sense of purpose, Laure Philip, now Development Manager, Major Gifts at The George Institute, made the challenging but fulfilling switch from academia to philanthropy a few years ago.

“Most people don’t know that I was formerly a French History lecturer and did my thesis on the French Revolution of 1789! I was raised in France, and lived for almost a decade in the UK, where I completed my PhD, before moving to Sydney for a postdoctoral position.”