Dementia and blood pressure

RECALL-Pilot: REducing Cognitive decline and dementiA by Lowering bLood pressure Pilot


Dementia is a decline in thinking skills that affects our ability to conduct day-to-day activities. It is not a normal part of ageing however there is a greater risk of dementia as we age. There are currently around 472,000 people affected by dementia in Australia, which is predicted to double in the next 35 years.

Studies have shown that high blood pressure increases the risk of dementia. Some studies suggest that medication to lower blood pressure might help reduce the risk of dementia but there is insufficient evidence for clear recommendations. The RECALL-Pilot trial aims to address this gap in the current body of research.


To encourage nationwide participation, RECALL-Pilot is trialling a new online approach to clinical trials, which will inform the future design of a larger clinical trial on dementia risk reduction.

Research Methodology

  • There are no face-to-face appointments in this study except for two blood tests – participants will carry out the rest of the pilot trial online from home. 
  • Eligible adults aged 70 or older will be asked to take a low-dose blood pressure medication for 60 days.
  • Participants will need to have an email address, access to the internet and a computer/tablet to complete online assessments and cognitive tests. For more information on eligibility, visit

Current Status

Currently recruiting via GP practices, social media platforms, retirement villages, and other potentially applicable healthcare organisations and special interest community groups/clubs.